GLP-1 Titration Schedules Explained
By DoseWise Team ·
GLP-1 medications are typically started at a low dose and increased gradually over several weeks — a process called titration. Rather than jumping straight to a target dose, a titration ladder holds each dose level for a fixed period (often four weeks) before stepping up, then settles into an ongoing "maintenance" dose once titration is complete.
Why titrate at all
Gradually increasing the dose gives the body time to adjust, which is the standard
approach documented across GLP-1 product labeling. A titration schedule is really just
a list of { dose, duration } steps — for example:
- Weeks 1–4: 0.25 mg
- Weeks 5–8: 0.5 mg
- Weeks 9–12: 1 mg
- Weeks 13+: 2.4 mg (maintenance)
Maintenance is open-ended
The maintenance step is different from the others: it doesn't have a fixed end date — it continues until a prescriber changes the plan. Our titration schedule generator models this directly: every step in a ladder has a duration except optionally the last one, which can be left open-ended and simply continues at the same dose.
This article is educational only and does not constitute medical advice. Always follow the titration schedule set by your prescriber.